Tuesday, June 9, 2009

Key Questions

Would an embryo about to die choose life in a trash can or life on a petri dish?

Is potential enough alone?

So do we experiment on it or do we let it die?

Would that be human cruelty?

How do adult stem cells evolve during development and how are they maintained in the adult? Are they "leftover" embryonic stem cells, or do they arise in some other way?

What would happen if embryonic stem cells prove to cure all the diseases it promises to? How will we be able to keep producing embryonic stem cells at the rate of the demand?

A History of Stem Cell Research

History

A stem cell is a unique type of cell which has the potential to transform into a variety of human cells. For example, it can transform into a muscle, blood, or brain cell. This of course, creates potential to cure diseases but brings up many uncomfortable moral issues.

A Timeline of the History of Stem Cells:

- 1950s: Discovery of the Stem cell in the bone marrow
- 1960s: Discovery of the stem cell in the brain
- 1981: Scientists derive the stem cells of embryos from mice
- 1998: Successful at deriving stem cells from the human and culturing it
- 2006: Induced pluripotent stem cells is introduced

There are two types of stem cells: adult and embryonic stem cells. Each has their own unique properties, limitations and abilities. The embryonic stem cell is the type that causes the most controversy, because as its name implies, it is derived from an embryo.

Adult stem cells, also called limited or somatic, are stem cells which are found in developed organs/tissues of the human body. The most famous places are the bone marrow and the umbilical cord. Adult stem cells are limited in use because they can only be applied to areas from which they originated in. For example, a bone marrow stem cell will only be effective if reinserted in the bone marrow. Another problem with adult stem cells is that they are difficult to detach from the organ and when detached, it is very difficult to cultivate and duplicate in the lab. Adult stem cells cannot grow outside of the body.

Embryonic stem cells, also called unlimited, are derived from the 3 day old embryo. These embryos generally have been donated by fertility clinics, and have been created through vitro or artificial fertilization. Embryonic stem cells are more versatile as they can develop into ANY type of cell under ther right direction. Embryos generally flourish when culured, and have the capability to keep duplicating one year after its separation from the original body. Although the embryonic stem cells hold more potential for a cure, it has created much controversy among america and the world as some view the embryo as much as a human.

Terms to Know:
Specialized Verses Unspecialized: An unspecialized stem cell is one that has not transformed into any type of cell nor hold designs to function as a particular tissue. A specialized cell, such as a blood tissue, carries a specific function only.
Differentiation: the proccess of an unspecialized stem cell turning into a specialized stem cell.
Induced Pluripotent Stem Cells: Adult cells that have been genetically engineered to have characteristics of the embryonic stem cell
Somatic Nuclear Transfer: Also called therapeutic cloning, this proccess is when the nucleus of an unfertilized egg cell is removed and replaced with the nucleus of the desired cell the experimenters want to form. Is allowed under supervision to duplicate.

Arguments For and Against

The Science: Embryonic stem cell research has a great deal of potential. The estimate of lives it can save is over 100 million people, all suffering from diseases such as Alzheimer’s, Parkinson’s, leukemia, or conditions such as being paralyzed. The potential of these stem cells is being restricted by laws against their use in research. While they have not been tested in vivoyet, it is widely believed that they can solve many problems that other types of stem cells cannot do. It is also much easier to use embryonic stem cells than any other kind, as adult stem cells are much harder to acquire and induce to be pluripotent. Time is being wasted deliberating the effectualness of adult stem cells while perfectly usable embryonic stem cells that would never be able to grow into human beings are being thrown out daily.

The Ethics: Embryonic stem cells most often used in research are the leftovers in fertility clinics, the extra when a couple successfully has a child and there are more embryos left. When these are not used, they are most often thrown out and go to waste. The living who are suffering from many different types of conditions that could be cured or at the very least alleviated with the knowledge that stem cell research could give us need more help than the ideals that are protected every time an embryo- a three-day-old clump of 100 cells, without a brain or a heart, and very little specifically human about it- not lucky enough to be used in fertility treatments is thrown out rather than experimented on.

Anti-Research:

The Science: Adult stem cells are a better choice to use for research and therapy. They can replace embryonic stem cells very easily because they can be retrieved from the person who needs them, thereby reducing the risk of rejection inherent in embryonic cells that do not come from the person who needs them, and they also do not have the ability of embryonic stem cells to divide indefinitely, so tumors that are created when that happens, referred to as teratomas, are not thought to happen in patients whose treatment involves adult stem cells. Also, embryonic stem cells aren’t the only ones that are pluripotent. Induced pluripotent stem cells- adult stem cells that have been modified to become pluripotent- are a viable possibility and have been shown to yield positive results, with very close to if not exactly the same capabilities as embryonic pluripotent stem cells.

The Ethics: A human is a human no matter its age, at three days past conception or a fully grown adult. An embryo of 100 cells is still an embryo, with the potential to grow into a human being, and to take away that potential is tantamount to murder. As a human being, the embryo has rights, too, and those rights cannot be ignored- it is wrong to experiment on that embryo, just as it is wrong to experiment on a fully grown human being without consent. Also, when a use such as curing cancer or other diseases is found, the demand will go up, as opposed to the fact that they are just needed for research at the moment. Fertility clinics will not be able to handle that demand just from leftovers- and new, even less humane ways of creating embryos for medicinal purposes will be created.

A Solution?

The usage of embryonic stem cells has been a huge controversy between large groups of opposing sides -- there is no easy solution. On one hand, they have the potential to be the cure for the world's greatest disease. Yet, is the cost of the potential human being worth this? Both sides have very valid points which cannot be ignored, so the best solution there is to find a compromise between the two.

This issue needs to be dealt carefully and sensitively, with an open mind to all sides of the argument. The best solution as of the moment, since there is so much still to learn about stem cells, is to continue research under strict supervision from the government.

As time and time progresses, if stem cell fulfills the potential it is currently promising at the moment, more severe actions need to be taken. Research is only acceptable at the moment because it is using the leftovers from fertility clinics to save lives of possibly millions. This question was asked by an anonymous user: "What happens when the leftovers run out? Where are we going to find resources to feed the mass need for embryonic stem cells?"

The problems of stem cell research are only in the warning stages at the moment, there is no doubt that these problems will get more complicated as the research continues. Governments should proceed with caution and continue to listen to the voice of the people.

What Can I Do?

Know your facts. This is first and most important step to master before you can involve yourself in the issue. Make sure to research the information in depth before you form your own opinion, because you do not want to make arguments off false assumptions from what you think you know.

Stay informed. Be aware of future voting that will most likely take place on stem cell research and use. Know the government's stand on stem cell research, and the latest discoveries on stem cells.

Keep an open mind. After you have formed your own opinion about whether or not you are pro or against stem cell research, it is important to listen carefully to what the other side has to say. If everybody sticks stubbornly to their opinion, a solution can never be reached.

Speak out. Whether in the form of voting, online blogging, or school assignments, make your voice heard. Not only will you speak out your opinion, you are bringing knowledge to more people simply by speaking out. It is time that people stop living in ignorance and acknowledge the global issues of today.

Pursue a career in stem cell research. Fellow teens, this is for you. If you are unsure of what career to pursue, why not study stem cells and major in college in science? Your efforts, creativity, and thought will prove to be incredibly valuable as stem cells will grow to be a bigger controversy with more complications.

Monday, June 8, 2009

More Links



A brief introduction to stem cells, how they grow and develop:


A not-so-brief, more informative discussion of stem cells:


Adult stem cells vs. embryonic:


Another video on stem cells and how they work: http://www.kqed.org/quest/television/view/326?gclid=CIS7ubu58poCFSMSagodLU17dg

Politics:




Barack Obama's stance on stem cells:


Works Cited

"Tell Me About Stem Cells." Web.8 Jun 2009. .

Kinsley, Michael. "The False Controversy of Stem Cells." 23 05 2004 Web.8 Jun 2009. .

"The Stem Cell Controversy." PBS. PBS. 8 Jun 2009 .

Stem Cell Basics . In Stem Cell Information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2009 [cited Monday, June 08, 2009] Available at